MICHAEL, Olugbenga Samuel – Bowen University

MICHAEL Olugbenga Samuel, PhD

Lecturer I

Biography

MICHAEL, Olugbenga Samuel Ph.D, is a Lecturer at the Department of Physiology, Faculty of
Basic Medical and Health Sciences, College of Health Sciences, Bowen University, Iwo, Osun
State, Nigeria. His research interest over the years has focused on the cardiometabolic
interactions that affect physiological processes in the body. His work on cardiovascular, renal
and hepatic metabolic dysregulation in metabolic syndrome has made significant contribution to
ongoing investigations to provide therapeutics for the management of metabolic syndrome.
Microbiome research and its application in health and disease especially its involvement in the
pathogenesis or management of cardiometabolic disorders, non-alcoholic fatty liver diseases,
polycystic ovary syndrome has been one of his research interest. Furthermore, He explored the
use and understanding of the mechanism of plant phytochemicals, neutraceuticals, pharmafoods
and diets for the treatment of diseases. He has published several scientific journals and
conference proceedings in local and international journals. He is a member of many scientific
and professional bodies like Physiological Society, UK, European society of cardiologist,
international society of hypertension, and Physiological Society of Nigeria

Education

Ph.D. Physiology degree (2018)
M.Sc. Physiology degree (2011)
B.Sc. Physiology degree (2006)

Publications

Islam, S., Thangadurai, D., Adetunji, C.O., Michael, O.S., Nwankwo, W., Kadiri, O., Anani, O.A., Makinde, S., Adetunji, J.B. (2020). Nanomaterials: Applications in Biomedicine and Biotechnology. In: Kharisov B. (eds) Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications. Springer, Cham.
Michael, O.S., Dibia, C.L., Soetan, O.A., Adeyanju, O.A., Oyewole, A.L., Badmus, O.O., Adetunji, C.O., Soladoye, A.O. (2020). Sodium acetate prevents nicotine- induced cardiorenal dysmetabolism through uric acid/creatine kinase- dependent pathway. Life Sciences 257: 118127 (An international journal of molecular, cellular and functional sciences published by Elsevier) doi.org/10.1016/j.lfs.2020.118127
Michael, O.S., Dibia, C.L., Adeyanju, O.A., Olaniyi, K.S., Areola, E.D., Olatunji, L.A. (2020). Estrogen-progestin oral contraceptive and nicotine exposure synergistically confers cardio-renoprotection in female Wistar rats. Biomed. Pharmacother. 129: 110387 (An international journal of clinical and basic medicine and pharmacology published by Elsevier).
Adegoke, T.E., Sabinari, I.W., Usman, T.O., Abdulkareem, T.O., Michael, O.S., Adeyanju, O.A., Dibia, C., Omotoye, O.O., Oyabambi, A.O., Olatunji, L.A. (2020). Allopurinol and valproic acid improve cardiac triglyceride and Na + -K + -ATPase activity independent of circulating aldosterone in female rats with glucose intolerance, Arch. Physiol. Biochem (An international journal of metabolic diseases published by Taylor and Francis, UK).
Adeyanju, O.A., Falodun, T.O., Michael, O.S., Soetan, O.A., Oyewole, A.L., Agbana, R.D. (2020). Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid - a familiar foe. Naunyn Schmiedebergs Arch. Pharmacol. 393 (6): 1055-1066 (An official publication of the German society of experimental and clinical pharmacology and toxicology published by Springer).
Adeyanju, O.A., Michael, O.S., Soladoye, A.O. Olatunji LA (2020). Blockade of mineralocorticoid receptor ameliorates oral contraceptive-induced insulin resistance by suppressing elevated uric acid and glycogen synthase kinase-3 instead of circulating mineralocorticoid. Arch. Physiol. Biochem 126:3, 225-234, (An international journal of metabolic diseases published by Taylor and Francis, UK)
Oyewole, A.L., Oyafemi, K.O., Badmus, K.S., Omoleye, J.O., Abubakar, M.F., Adeniyi- Raheem, O., Amedu, A., Lawal, D.L., Ijiyode, A.O., Yussuf, A.O., Ishola, S.S., Sulaimon, F.A., Alli-Oluwafuyi, A.O., Nafiu, A.B., Akinola, O., Olajide, O.J., Amin, A., Abdulmajeed, W.I., Michael, O.S., Adeyanju, O.A., Ogunjimi, G.L. (2020). Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers. Journal of Neuroscience Methods.(An international journal of neuroscience research methods published by Elsevier)
Bamidele, O., Adebayo, O., Adedayo, L.D., Michael, O.S., Ojo, A.O., Arokoyo, D.S. (2020). Ethanol extract of Myristica fragrans (houtt) exhibits hepato-renal protective effects against lead-induced toxicity in Wistar rats. Drug Discovery 14(33), 170-179.
Omolekulo, T.E., Michael O.S., Olatunji, L.A. (2019). Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by suppressing uric acid”. Biomed. Pharmacother. 110: 869–877. (An international journal of clinical and basic medicine and pharmacology published by Elsevier)
Dangana, E.O., Michael, O.S., Omolekulo, T.E., Areola, E.D., Olatunji, L.A. (2019) “Enhanced hepatic glycogen synthesis and suppressed adenosine deaminase activity by lithium attenuates hepatic triglyceride accumulation in nicotine-exposed rats”. Biomed. Pharmacother. 109: 1417–1427. (An international journal of clinical and basic medicine and pharmacology published by Elsevier)
Omolekulo, T.E., Michael O.S., Olatunji, L.A. (2019) “Sodium acetate improves disrupted glucoregulation and hepatic triglyceride content in insulin-resistant female rats: involvement of adenosine deaminase and dipeptidyl peptidase-4 activities”. Naunyn Schmiedebergs Arch. Pharmacol. 392: 103-116. (An official publication of the German society of experimental and clinical pharmacology and toxicology published by Springer).
Olatunji, L.A., Adeyanju, O.A., Michael, O.S., Usman, T.O., Tostes, R.C., Soladoye, A.O. (2019) “ Ameliorative effect of low-dose spironolactone on obesity and insulin resistance is through replenishment of estrogen in ovariectomized rats”. Can. J. Physiol. Pharmacol. 97(1): 65-74. (An international journal of physiology and pharmacology published by NRC Research Press, Canada)
Omolekulo, T.E., Areola, E.D., Badmus, O.O., Michael, O.S., Kim, I. and Olatunji, L.A. (2018) “Adenosine deaminase and xanthine oxidase inhibitory effect of valproic acid abates glucose dysregulation and liver triglyceride accumulation independent of corticosteroids in estrogen/progestin-treated female rats”. Can. J. Physiol. Pharmcol. 96(11): 1092-1103. (An international journal of physiology and pharmacology published by NRC Research Press, Canada)
Badmus, O.O., Michael, O.S., Rabiu, S. and Olatunji, L.A. (2018). Gestational glucocorticoid exposure disrupts glucose homeostasis that is accompanied by increased endoglin and DPP-4 activity instead of GSK-3 in rats”. Environ. Toxicol. Pharmacol. 60: 66-75. (An international journal of toxicology and pharmacology published by Elsevier)
Michael, O.S., and Olatunji, L.A. (2018) “Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen progestin therapy”. Arch. Physiol. Biochem. 124 (2): 139-148. An international journal of metabolic diseases published by Taylor and Francis,
Michael, O.S., and Olatunji, L.A. (2018) “Nicotine exposure suppresses hyperinsulinemia and improves endothelial dysfunction mediators independent of corticosteroids in insulin-resistant oral contraceptive-treated female rats”. Drug Chem. Toxicol. 41(3): 314-323. An international journal of metabolic diseases published by Taylor and Francis, UK)
Olatunji, L.A., Michael, O.S., Adeyanju O.A., Areola E.D., Soladoye A.O. (2017) “Anti- inflammatory and antithrombotic effects of nicotine exposure in oral contraceptive- induced insulin resistance are glucocorticoid-independent”. Pharmacol. Rep. 62(3): 512-519. (An official journal of the Institute of Pharmacology of the Polish Academy of Sciences published by Elsevier).
Olatunji, L.A., Michael, O.S., Adewumi, F.O., Aiyegboyin, I.J. and Olatunji, V.A. (2012) “Combined estrogen-progestogen but not progestogen-only oral contraceptive alters glucose tolerance and plasma lipid profile in female rats”. Pathophysiology 19: 29-34. (An official journal of the International Society for Pathophysiology, published by Elsevier)
Olaleye S.B., Ige A.O., Michael O.S., and Owoyele B.V. (2012) “Analgesic and Anti- Inflammatory effects of Ethanol Extracts of Buchholzia coriacea Seeds in Male Rats”. Afr. J. Biomed. Res. 15(3):171-176.
Olatunji, L.A. Aaron, A.O., Michael O.S. and Oyeyipo, I.P. (2011) “Water ingestion affects orthostatic challenge-induced blood pressure and heart rate responses in young healthy subjects: gender implications”. Niger. J. Physiol. Sci. 26 (1): 11-18. (An official publication of The Physiological Society of Nigeria). . PMID: 22314980)
Olatunji, L.A, Oyeyipo, I.P., Micheal, O.S. and Soladoye, A.O. (2008) “Effect of dietary magnesium on glucose tolerance and plasma lipid during oral contraceptive 7 | Page administration in female rats”. Afr. J. Med. Med. Sci. 37(2): 135-139. (An official publication of College of Medicine, University of Ibadan).